Blar i forfatter "Høye, Eirik"

Viser treff 1-4 av 4

    • A comprehensive framework for analysis of microRNA sequencing data in metastatic colorectal cancer 

      Høye, Eirik; Fromm, Bastian; Böttger, Paul H.M.; Domanska, Diana; Kristensen, Annette Torgunrud; Lund-Andersen, Christin; Abrahamsen, Torveig Weum; Fretland, Åsmund Avdem; Dagenborg, Vegar Johansen; Lorenz, Susanne; Edwin, Bjørn von Gohren; Hovig, Eivind; Flatmark, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-14)
      Although microRNAs (miRNAs) contribute to all hallmarks of cancer, miRNA dysregulation in metastasis remains poorly understood. The aim of this work was to reliably identify miRNAs associated with metastatic progression of colorectal cancer (CRC) using novel and previously published nextgeneration sequencing (NGS) datasets generated from 268 samples of primary (pCRC) and metastatic CRC (mCRC; ...

    • MapToCleave: High-throughput profiling of microRNA biogenesis in living cells 

      Kang, Wenjing; Fromm, Bastian; Houben, Anna J.; Høye, Eirik; Bezdan, Daniela; Arnan, Carme; Thrane, Kim; Asp, Michaela; Johnson, Rory; Biryukova, Inna; Friedländer, Marc R. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-16)
      Previous large-scale studies have uncovered many features that determine the processing of microRNA (miRNA) precursors; however, they have been conducted in vitro. Here, we introduce MapToCleave, a method to simultaneously profile processing of thousands of distinct RNA structures in living cells. We find that miRNA precursors with a stable lower basal stem are more efficiently processed and also ...

    • MirGeneDB 2.1: toward a complete sampling of all major animal phyla 

      Fromm, Bastian; Høye, Eirik; Domanska, Diana; Zhong, Xiangfu; Aparicio-Puerta, Ernesto; Ovchinnikov, Vladimir; Umu, Sinan Ugur; Chabot, Peter J; Kang, Wenjing; Aslanzadeh, Morteza; Marmol-Sanchez, Emilio; Urgese, Gianvito; Johansen, Morten; Hovig, Eivind; Hackenberg, Michael; Friedländer, Marc R.; Peterson, Kevin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
      We describe an update of MirGeneDB, the manually curated microRNA gene database. Adhering to uniform and consistent criteria for microRNA annotation and nomenclature, we substantially expanded MirGeneDB with 30 additional species representing previously missing metazoan phyla such as sponges, jellyfish, rotifers and flatworms. MirGeneDB 2.1 now consists of 75 species spanning over ∼800 million ...

    • T cell receptor repertoire sequencing reveals chemotherapy-driven clonal expansion in colorectal liver metastases 

      Høye, Eirik; Dagenborg, Vegar Johansen; Kristensen, Annette Torgunrud; Lund-Andersen, Christin; Fretland, Åsmund Avdem; Lorenz, Susanne; Edwin, Bjørn von Gohren; Hovig, Eivind; Fromm, Bastian; Inderberg, Else Marit; Greiff, Victor; Ree, Anne Hansen; Flatmark, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-10)
      Background - Colorectal liver metastasis (CLM) is a leading cause of colorectal cancer mortality, and the response to immune checkpoint inhibition (ICI) in microsatellite-stable CRC has been disappointing. Administration of cytotoxic chemotherapy may cause increased density of tumor-infiltrating T cells, which has been associated with improved response to ICI. This study aimed to quantify and ...